: Their relationship reaches a breaking point when Leyla discovers Lauren bribed her way into a residency spot.

: Helen and Max track the infection's movement through the Emergency Department.

As Dr. Max Goodwin and Dr. Helen Sharpe prepare to leave for London to start a new life together, they find themselves pulled back into the hospital one last time. Their departure is halted when a —a rare bacterial infection—rapidly spreads through New Amsterdam, leading to nine simultaneous "Code Blues" and multiple patient deaths. The Search for a Source The medical team races to find the origin of the outbreak:

The story of the New Amsterdam episode (Season 4, Episode 10) serves as a high-stakes mid-season finale centered on a deadly medical crisis that interrupts a major life transition for the show's lead characters. The Departure and the Crisis

: Floyd learns that Lyn Malvo is pregnant, adding a new layer of complexity to their relationship.

Standard treatments and modern antibiotics prove ineffective against the antibiotic-resistant strain. Facing a growing death toll, Max proposes a risky solution using , a drug from the 1950s that was pulled from the market because it causes severe kidney failure. To save the patients, the team decides to administer the drug while simultaneously placing every patient on dialysis to mitigate the damage. Dr. Walsh volunteers to be the first test subject; he survives, proving the treatment works. Emotional Subplots

: Iggy assists grieving parents who initially believe their son's death is a TikTok prank. He eventually helps them confront the reality of their loss at the morgue.