Bills Vs Detroit Lions: Nfl Buffalo

The Bills historically hold the upper hand in this series, which began in 1972. The Bills lead 8-4-1.

Their most recent 2024 clash saw a combined 90 points , with the Bills outlasting the Lions 48-42 at Ford Field. Key Player Spotlight (2026 Rosters) NFL Buffalo Bills vs Detroit Lions

How Lions and Bills match up ahead of game of the season - ESPN The Bills historically hold the upper hand in