: High glucose levels can suppress the transcriptional activity of RAR/RXR, promoting oxidative stress and cardiomyocyte apoptosis . This is linked to the phosphorylation and degradation of the receptors via the JNK pathway.
Studies in F9 and P19 cell lines reveal complex "functional redundancies" where different types of RAR (α, β, γ) can sometimes substitute for one another: FrSi_TCRSR.part5.rar
: In malignant brain tumors like glioblastoma, RAR-independent RXR signaling has been identified as a factor that supports the proliferation and survival of stem-like tumor cells. : High glucose levels can suppress the transcriptional
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