: Excessively self-confident and sarcastic, Nate often clashes with authority figures, particularly his social studies teacher, Mrs. Godfrey .

The series features a recurring cast of friends, rivals, and family members:

: He is a gifted cartoonist, a skilled chess player, and a drummer for his rock band, Enslave the Mollusk .

: Nate’s best friend and the "voice of reason."

: Nate’s single, middle-aged father who refuses to let Nate get a dog. The Evolution of the Franchise Big Nate, Small Screen: An Interview with Lincoln Peirce

: Nate’s long-time crush, though his feelings are famously unrequited.