Accel Core and Process cards (PCIe) or the older PCI-X cards.
It is most stable on Mac OS X 10.6.8 (Snow Leopard) or 10.8.5 (Mountain Lion) . On Windows, Windows 7 SP1 is the gold standard. Avid Pro Tools HD 10
You must ensure you are installing AAX 32-bit or TDM/RTAS versions of plugins. Modern 64-bit-only plugins will not show up. Accel Core and Process cards (PCIe) or the older PCI-X cards
Are you planning on with older PCIe cards, or are you trying to modernize an existing HD 10 session for a newer version of Pro Tools? non-internet-connected Mac Pro "Cheese Grater
On a dedicated, non-internet-connected Mac Pro "Cheese Grater," HD 10 is notoriously stable for tracking large bands.
Some legendary TDM plugins were never ported to the 64-bit AAX format.