23484.rar -

: This identifies a "drugable" target that is distinct from the nitric oxide/cGMP pathway.

: Protein Kinase G Iα (PKG Iα) is usually activated by cGMP, but it can also be activated by "oxidative stress" (specifically the formation of a disulfide bond at Cys42).

: Targeting the Oxidative Activation of Protein Kinase G Iα: A Novel Therapeutic Approach for Hypertension. 23484.rar

: Use of C57BL/6 mice and specialized Cys42Ser KI (knock-in) mice that are resistant to PKG oxidative activation.

: Summarize how the study identifies a specific redox-sensitive mechanism in PKG Iα that contributes to blood pressure regulation and how small molecules can target this to treat hypertension without the side effects of traditional vasodilators. 2. Introduction : This identifies a "drugable" target that is

: Measurement of blood pressure in conscious, freely moving mice using telemetric probe catheters .

If you are looking for the or figures originally contained within that RAR file to include in your paper, you can often find them in the "Supplementary Materials" section of the original Science publication. To help you further, could you tell me: : Use of C57BL/6 mice and specialized Cys42Ser

Are you writing this for a or a journal submission ?